Transactivation of the EGFR by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells
نویسندگان
چکیده
Abbreviations: Egr-1, early growth response gene-1; EGFR, epidermal growth factor receptor; ERK, extracellular-regulated kinases; MAP kinases, mitogen-activated protein kinases; PAI, pathogenicity island; cag, cytotoxin associated genes; PMA, Phorbol-12myristate-13-acetate; MOI, Multiplicity of infection; GAPDH, glyceraldehyde-3phosphate dehydrogenase; PCR, polymerase chain reaction; PBS, phosphate buffered saline; EMSA, electrophorectic mobility shift assay; JNK, c-Jun N-terminal kinase.
منابع مشابه
Transactivation of the epidermal growth factor receptor by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells.
BACKGROUND AND AIMS Helicobacter pylori, in particular cytotoxin associated gene (cag)+ strains, have been shown to enhance gastric epithelial cell proliferation in vivo, an effect that likely contributes to gastric carcinogenesis. Early growth response gene 1 (Egr-1) is a crucial regulator of cell growth, differentiation, and survival, which is known to play a role in carcinogenesis and cancer...
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